Cerebrospinal fluid microRNAs as potential biomarkers in Alzheimer’s disease

Alzheimer’s disease (AD) is the leading form of dementia worldwide, but its early detection and diagnosis remain a challenge. MicroRNAs (miRNAs) are group small endogenous RNA molecules that regulate mRNA expression. Recent evidence suggests miRNAs play an important role in five major hallmarks AD pathophysiology: amyloidogenesis, tauopathy, neuroinflammation, synaptic dysfunction, neuronal death. Compared to traditional biomarkers AD, display greater degree stability cerebrospinal fluid. Moreover, aberrant changes miRNA expression can be measured over time monitor guide patient treatment. Specific profiles combinations may also used distinguish subjects from normal controls other causes dementia. Because these properties, now being considered as promising potential AD. This review comprehensively summarizes diagnostic regulatory roles